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Evaluation of Drug-Induced Serious Hepatotoxicity (eDISH) plots are a key tool used to assess liver toxicity in clinical trials. Our tool implements the standard eDish workflow as a free and open …
The composite eDISH plot is a visualization of peak on-treatment changes in liver test results both as multiples of the upper limit of normal (xULN) and multiples of the subjects' baseline (xBLN) …
To improve the reporting and detection of Hy’s law cases in clinical trial database, the FDA has recently introduced the Evaluation of Drug-Induced Serious Hepatotoxicity (eDISH) plot, which …
The objective of this analysis was to use eDISH to determine if patients with NASH treated with OCA show increased markers of liver injury or whole liver dysfunction.
Evaluation of Drug-Induced Serious Hepatotoxicity, or eDISH, plots are a key tool used to assess liver toxicity in clinical trials. Standard properties and workflows for static eDish plots are well …
Mar 1, 2011 · The eDISH approach is an efficient and effective way to organize and examine large liver safety databases for randomized controlled clinical trials. It greatly facilitates a systematic …
eDISH (evaluation of Drug-Induced Serious Hepatotoxicity) is a well described method/tool that visually represent liver laboratory data of ALT/AST and Total Bilirubin in form of graph by …
Apr 20, 2024 · The eDISH plot is a log-log scatter plot where the x-axis is the peak on-treatment alanine aminotransferase (ALT) and the y-axis is the peak on-treatment total bilirubin (BILI), both …
eDISH has a drill-down capability from the summary views of all subjects to a time-course view of individual subject, which opens the subject’s demographic characteristics, liver-testing results …
Mar 21, 2018 · The eDISH tool was created using commercial software named SAS/IntrNet as the platform, designed to mimic the thought process that goes into medical differential diagnosis of …
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